Serum triglyceride and apolipoprotein A1 as dynamic biomarkers in extranodal NK/T-cell lymphoma (ENKTL): A multicenter retrospective and prospective validation study.

ABSTRACT: Extranodal NK/T-cell lymphoma (ENKTL), an aggressive non-Hodgkin lymphoma subtype, exhibits understudied links between lipid metabolism and clinical outcomes. We analyzed 1,017 patients newly diagnosed with ENKTL and matched controls, with longitudinal LC-MS-based metabolomic profiling (n = 29) and pretreatment tumor transcriptomic analysis (n = 65). Multivariable Cox models evaluated lipid biomarkers. Patients with ENKTL showed significantly elevated triglycerides (TG) and reduced apolipoprotein A1 (ApoA1) vs. controls (both p < 0.001). Elevated TG (progression-free survival [PFS] HR = 1.33, 95% CI 1.04-1.69; overall survival [OS] HR = 1.37, 95% CI 1.04-1.80) and reduced ApoA1 (PFS HR = 1.47, 95% CI 1.07-2.03; OS HR = 1.65, 95% CI 1.15-2.38) independently predicted inferior survival (all

SUBMITTER: Wang JN 

PROVIDER: S-EPMC12764532 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature