MGDB: A Novel Bioinformatics Quality Control Tool for Clinical Next-Generation Sequencing.

ABSTRACT:

Background and objectives

Next-generation sequencing (NGS) is transforming clinical diagnostics by enabling the detection of genetic variation with unprecedented precision. However, successful implementation of NGS workflows necessitates stringent quality control. This study introduces Molecular Genetics Dashboard (MGDB), a novel bioinformatics tool designed to enhance quality control in clinical NGS workflows.

Methods

Using the Python dash framework for visualizations and MySQL databases, we have developed a novel tool for variant-level monitoring of clinical NGS sequencing runs. MGDB uses a docker-compose containerization for improved portability and can flexibly include or exclude samples from accumulated statistics with notes from interpreters.

Results

MGDB facili

SUBMITTER: Gayap HT 

PROVIDER: S-EPMC12764754 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature