Transcriptomic analysis reveals the potential role of TOE1 in hepatocellular carcinoma.

ABSTRACT: This study integrates bioinformatics analysis and in vitro experiments to elucidate the role of Target of EGR1 (TOE1) in hepatocellular carcinoma (HCC) progression. TOE1, a deadenylase belonging to the DEDD exonuclease superfamily, is primarily localized in the Cajal bodies of the nucleus. While the biological functions of TOE1 have been partially characterized, its role in cancer remains unclear. We analyzed TOE1 expression, its correlation with clinicalpathological features, prognosis, and immune infiltration in HCC using databases and platforms such as The Cancer Genome Atlas (TCGA), COSMIC, cBioPortal, and TIMER. Additionally, we validated TOE1 expression levels in clinical samples. Through the knockdown of TOE1 in HCC cell lines and subsequent RNA-seq analysis, we explored its functio

SUBMITTER: Ao JY 

PROVIDER: S-EPMC12764802 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature