Local field potentials survey to guide DBS programming in Parkinson's disease: a clinical-neurophysiological longitudinal study.

ABSTRACT: Deep Brain Stimulation (DBS) programming in Parkinson's disease relies on clinical evaluation, yet beta-band activity in local field potentials (LFPs) may offer objective guidance. We evaluated LFP-guided contact selection against clinical programming (CP) at initial monopolar review and long-term follow-up. Bipolar LFPs were recorded in patients with sensing-enabled DBS systems, where central levels were clinically chosen. Three methods based on beta peak amplitude were tested: Broad-Bipolar (non-adjacent rings), Narrow-Bipolar (contiguous rings), and Segment-Bipolar (horizontal segments). Performance was assessed using correlation, agreement, and selection similarity with CP and compared to random selection. Narrow-Bipolar showed the strongest correlation and agreement with CP at both ti

SUBMITTER: D'Onofrio V 

PROVIDER: S-EPMC12764821 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature