Cutting-edge bayesian deep learning and statistical strategies for bias mitigation in COVID-19 detection via chest x-ray imaging.

ABSTRACT: Chest radiography (CXR is widely used for triage and follow-up of pulmonary disease, yet COVID-19 classification remains vulnerable to bias, label noise, and domain shift. We propose a multi-stage Bayesian deep learning framework that combines lung segmentation, segmentation-guided classification, calibrated ensembling, and uncertainty estimation to classify four classes (COVID-19, normal, viral pneumonia, bacterial pneumonia) and to grade COVID-19 severity. Models are trained and tested on 1,531 CXRs (100 COVID-19 images from 70 patients; 1,431 non-COVID images from ChestX-ray14) with patient-wise splits. The final ensemble achieves 98.33% test accuracy; COVID-19 sensitivity reaches 100% on this split. Robustness is quantified by stress-testing five image degradations (Gaussian noise, mot

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12764913 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature