A migrasome-related LncRNA signatures for predicting prognosis and immunotherapeutic response in colorectal cancer.

ABSTRACT: Migrasome has recently been reported to regulate cell-cell communication in tumor progression. But the function of migrasome in CRC, especially its prognostic potential and association with long non-coding RNAs and tumor microenvironment has yet to be fully explored. Migrasome-related lncRNAs were identified based on transcriptome data from 650 CRC patients in the TCGA COREAD cohort. A prognostic signature was developed via the least absolute shrinkage and selection operator algorithm and Cox regression. The multimodal predicting model for prognosis of CRC patients was constructed and validated through Kaplan-Meier survival, ROC curve analysis, and nomogram construction. Patients were divided into high- and low-risk groups according to their prognostic signature and functional enrichment,

SUBMITTER: Cai J 

PROVIDER: S-EPMC12764946 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature