Polygenic prediction of cardiorespiratory fitness in the Trondelag health study (HUNT).

ABSTRACT: Cardiorespiratory fitness (CRF) has a strong genetic component and low CRF is a major risk factor for cardiovascular morbidity and mortality. The purpose of this study was to develop and validate a polygenic score (PGS) for CRF (CRF_PGS) and assess its associations with cardiovascular disease (CVD) and all-cause mortality. We hypothesized that the CRF_PGS would demonstrate similar cardioprotective benefits as the CRF phenotype. Effect estimates from a genome-wide association study on directly measured CRF in the Trøndelag Health Study (HUNT; n = 4525) were used in a Bayesian regression framework to develop multiple PGSs in an independent cohort from the UK Biobank (n = 65,165). The top performing score was applied in the HUNT target cohort, excluding the discovery sampl

SUBMITTER: Ovretveit K 

PROVIDER: S-EPMC12764957 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature