Identification of dysregulated gene clusters and pathways driving ocular surface squamous neoplasia progression.

ABSTRACT: Ocular Surface Squamous Neoplasia (OSSN) represents a spectrum of ocular malignancies that threaten vision and ocular integrity. To unravel the molecular mechanisms underlying OSSN progression, we conducted RNA-sequencing on conjunctival tissues from healthy individuals and patients with OSSN. Our analysis revealed marked alterations in the expression of genes implicated in inflammation, immune dysregulation, cell cycle regulation, and cellular stress responses. Notably, genes such as TP53, CXCL9, CXCL11, IL6, TNFα, MMP7, MMP9, GSTM1, IFNα, and IL1β showed significant dysregulation in OSSN samples compared to controls. Pathway enrichment analysis highlighted the activation of Interferon-α, Interferon-γ, and IL6/JAK-STAT3 signaling, alongside pathways regulating inflammatory response, p53 s

SUBMITTER: Goel K 

PROVIDER: S-EPMC12764983 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature