Estimated glucose disposal rate and frailty in middle and older aged adults from three prospective cohorts.

ABSTRACT: Insulin resistance (IR) has been associated with incident frailty. However, the precise association between the estimated glucose disposal rate (eGDR) and the development of frailty remains insufficiently understood. We hypothesized that a lower eGDR, indicating greater IR, would be associated with a higher risk of developing frailty and with accelerated frailty progression across cohorts. This study aimed to systematically investigate and clarify this association. Data were obtained from three prospective cohorts: the China Health and Retirement Longitudinal Study (CHARLS), the English Longitudinal Study of Ageing (ELSA), and the Health and Retirement Study (HRS). Frailty was assessed using the Rockwood Frailty Scale. Baseline eGDR, changes in eGDR, and cumulative eGDR from baseline to th

SUBMITTER: Li Y 

PROVIDER: S-EPMC12764994 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature