Rictor/mTORC2 signaling pathway mediates Benzo[a]pyrene-induced renal injury.

ABSTRACT: Benzo[a]pyrene (B[a]P) is a typical environmental persistent organic pollutant and a known nephrotoxicant. However, its toxicological profile under short-term, high-dose exposure conditions remains incompletely characterized. To address this, we established a C57BL/6J mouse model in which a single oral dose of 50 mg/kg B[a]P was administered. The results showed that time-dependent renal injury following Bla]P exposure. Within 3 days serum creatinine (Scr) and blood urea nitrogen (BUN) levels increased significantly (P < 0.05), coinciding with elevated renal malondialdehyde (MDA) content. Concurrently, superoxide dismutase (SOD) and catalase (CAT) activities, as well as total antioxidant capacity (T-AOC) were markedly reduced (P < 0.05). By days 7-14 days, the pathological changes shifted t

SUBMITTER: Han JQ 

PROVIDER: S-EPMC12765000 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature