Clinical and echocardiographic phenotype of cardiac wasting in patients with advanced cancer.

ABSTRACT:

Aims

Cardiac wasting-associated cardiomyopathy in patients with advanced cancer is characterized by loss of left ventricular (LV) mass and independently associated with poor prognosis. Better understanding of this very prevalent cardiomyopathy is urgently needed.

Methods and results

Overall, 398 patients with active, mostly advanced cancer without significant cardiovascular disease (mean LV ejection fraction [LVEF] 64.3 ± 0.2%) or active infection were prospectively examined (mean age 60 ± 1 years, 50% women, body mass index 25.0 ± 0.2 kg/m², 26% cachectic). Patients were categorized and compared by quartiles of LV mass/height². LVEF, global longitudinal strain (GLS), and anticancer therapy naive status were similar across quartiles. Patients in Q1 (low

SUBMITTER: Anker MS 

PROVIDER: S-EPMC12765034 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature