The impact of gut-liver-derived mediators on the organ crosstalk with brain, heart, and kidney: A systematic review.

ABSTRACT:

Introduction

The current understanding of interactions and crosstalk among essential organs remains incomplete, mainly due to the limitations of studies on the systemic mechanisms at play. The gut and the liver are essential for the functioning of the entire body, and their derived mediators circulate through blood or lymph, impacting other organs like the brain, heart, and kidneys.

Aim

This publication reviews gut-liver-derived mediators, which were tested and validated in vivo in humans and rodents, together with the current knowledge of their systemic effects on key vital organs.

Method

Original articles published up to February 2025, based on clinical trials or in vivo experimental models, were retrieved from PubMed and Web of Science.

Results

During this s

SUBMITTER: Bhargava S 

PROVIDER: S-EPMC12765073 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature