Prospective controlled study comparing patient-reported outcomes after daily online adaptive radiotherapy or conventional IGRT in patients with prostate cancer.

ABSTRACT:

Purpose

To compare patient-reported outcome measures (PROMs) in patients treated either with cone-beam CT (CBCT)-based online adaptive radiotherapy (oART) or with CBCT-guided conventional image guided radiotherapy (IGRT).

Materials and methods

In this prospective study with convenience allocation, patients with localized prostate cancer received 62 Gy/20 fractions using either daily CBCT-based oART or CBCT-guided conventional IGRT. PROMs (EPIC, QLQ-PR25, IPSS, NCI-PRO-CTCAE) were collected at baseline and at end of therapy. Changes in scores and clinically meaningful deterioration, based on established minimal clinically important differences (MCID), were analyzed.

Results

Seventy-four patients were included (oART: 58.1 %; IGRT: 41.9 %). Groups were demographically si

SUBMITTER: Kalinauskaite G 

PROVIDER: S-EPMC12765114 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature