Unleashing the biological power and chemical profile of <i>Paracaryum hedgei</i> extracts based on chromatographic, in vitro, and bioinformatic tools.

ABSTRACT: Studies evaluating the chemical constituents and pharmacological potential of Paracaryum species (family Boraginaceae) were limited. The current study was designed to investigate, for the first time, the chemical profile, antioxidant, enzyme-inhibitory, and cytotoxic properties of P. hedgei Aytaç & R.R. Mill. Roots extracts recorded the highest total phenolic content (24.72-91.16 mg GAE/g). About 33 compounds were identified, and the aerial parts extracts were dominated by rosmarinic acid, rutin, and sagerinic acid. In general, the root extracts exhibited greater antioxidant activity than the extracts from the aerial parts. Among the solvents, The 70 % EtOH extract of roots showed the highest antiradical (DPPH: 207.90 mg TE/g; ABTS: 238.08 mg TE/g), ion-reducing (FRAP: 384.99

SUBMITTER: Saka E 

PROVIDER: S-EPMC12765141 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature