Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden.

ABSTRACT: Blood-brain barrier (BBB) water exchange may serve as a sensitive early biomarker for Alzheimer's disease and age-related cognitive decline. This study applied a non-invasive multi-echo arterial spin labeling (ASL) technique to measure BBB water exchange time (Tex), cerebral blood flow (CBF), and arterial transit time (ATT) in 160 adults aged 50 years and older. Participants were classified as cognitively normal (CN), having subjective cognitive decline (SCD), or mild cognitive impairment (MCI). They were assessed for amyloid status and cerebrovascular burden. Compared to CN participants, Tex was significantly lower in both SCD (-9.5 %) and MCI (-14.5 %) groups, suggesting that reductions in BBB water exchange emerge early in the course of cognitive decline. In contrast, CBF was reduced on

SUBMITTER: Padrela BE 

PROVIDER: S-EPMC12765162 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature