Histidine-rich glycoprotein ameliorated lung ischemia-reperfusion injury in a mouse model.

ABSTRACT:

Background

Histidine-rich glycoprotein (HRG) is a multifunctional plasma glycoprotein involved in the regulation of various biological processes. Decreased plasma levels of HRG at 72 h after lung transplantation have been shown to be associated with severe primary graft dysfunction and poor transplant outcomes. In this study, we examined the effect of HRG supplementation on lung ischemia-reperfusion injury (IRI) in mice.

Methods

The experimental mice were divided into a Sham group and three IRI groups (n=5 each) that received phosphate-buffered saline, human serum albumin, or HRG (HRG/IRI group), respectively. The lung function, lung injury, neutrophil infiltration, cellular apoptosis, inflammatory mediators, neutrophil extracellular traps (NETs), translocation status of hig

SUBMITTER: Kubo Y 

PROVIDER: S-EPMC12765177 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature