Uric Acid, Arterial Stiffness and Blood Pressure: A Population-Based Cohort Study.

ABSTRACT:

Background and aim

Serum uric acid (SUA) has long been linked to elevated blood pressure (BP) in observational clinical studies. Nonetheless, data regarding the correlation between SUA and BP are controversial in randomized controlled trials and mendelian randomization research. Furthermore, it is yet unknown if there is a reciprocal relationship between SUA and BP. This study was conducted to explore the temporal relationship between SUA and BP and related risk factors.

Methods

In this cohort study, 27,581 participants free of hypertension and cardiovascular disease from 2010 to 2016 in the Kailuan study were included. Cross-lagged studies with repeated evaluation of BP and SUA were applied to identify the temporal relationship between SUA and BP. The brachial-ankle pulse w

SUBMITTER: Li L 

PROVIDER: S-EPMC12765212 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature