Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity.

ABSTRACT: Glioblastoma is the most common and aggressive primary brain cancer and shows minimal response to therapies. The immunosuppressive tumour microenvironment in glioblastoma contributes to the limited therapeutic response. Astrocytes are abundant in the central nervous system and have important immunoregulatory roles. However, little is known about their role in the immune response to glioblastoma¹. Here we used single-cell and bulk RNA sequencing of clinical glioblastoma samples and samples from preclinical models, multiplexed immunofluorescence, in vivo CRISPR-based cell-specific genetic perturbations and in vitro mouse and human experimental systems to address this gap in knowledge. We identified an astrocyte subset that limits tumour immunity by inducing T cell apoptosis throug

SUBMITTER: Faust Akl C 

PROVIDER: S-EPMC12765214 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature