Swimming motions evoke Piezo1-dependent Ca²⁺ events in vascular endothelial cells of larval zebrafish.

ABSTRACT: Calcium signaling in the vascular endothelium regulates vascular growth,^1,2 immune responses,³ and tone.⁴ Endothelial cells (ECs) are mechanosensitive,^5,6,7 and flow-driven shear stress is widely assumed to be the main trigger for EC Ca²⁺ responses in vivo.^8,9,10 Vascular ECs experience a range of distinct mechanical forces in vivo.^1,2,6,7 These include shear stress from blood flow, radial stretch from blood pressure, circumferential stretch from smooth-muscle-mediated vasodilation, and, in some parts of the animal, axial stretch from skelet

SUBMITTER: Jia BZ 

PROVIDER: S-EPMC12765218 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature