HEB Restrains Effector Gene Expression during Early CD8⁺ Memory Precursor T Cell Differentiation.

ABSTRACT: Memory T cells are essential for maintaining long-term adaptive immunity. Memory cell precursors and short-lived effector cells emerge from undifferentiated naïve T cells directly downstream of TCR signaling but little is known about how this lineage choice is regulated at the molecular level. The transcription factor HEB is known to be an important regulator of thymic T cell development, but how it functions in peripheral T cell differentiation is poorly understood. We assessed the role of HEB in the differentiation of memory-like T cell precursors by inducing TCR signaling in CD8 T cells in the context of memory-polarizing cytokines or inflammatory conditions and found that CD8 T cells from HEB-deficient mice underwent accelerated differentiation as compared to WT cells. Transcriptomic a

SUBMITTER: Leung JP 

PROVIDER: S-EPMC12765225 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature