Reactivating T cell immunity in Wnt-hyperactivated non-small cell lung cancer through a supramolecular droplet of carnosic acid and peptide.

ABSTRACT: The Wnt/β-catenin signaling pathway is renowned for its contribution to the immunosuppressive microenvironment in non-small cell lung cancer (NSCLC). Consequently, inhibiting this pathway has emerged as a promising strategy to enhance immune activation and reinstate T cell responses in cancer treatment. In this study, we initially investigate the metabolic characteristics of Wnt-hyperactivated NSCLC using mass spectroscopic detection in a mouse in-situ model and unveil its significant feature of acid accumulation at tumor sites. Building upon this discovery, we design an acid-sensitive peptide-carnosic acid (CA) supramolecular droplet (Pep1@CA), which leverages the acidic microenvironment characteristic of NSCLC for controlled release. By doing so, we aim to enhance targeting effici

SUBMITTER: Liu N 

PROVIDER: S-EPMC12765257 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature