Low expression of OXCT1 promote colorectal cancer liver metastasis by upregulating CDK8 and β-catenin via H3 acetylation.

ABSTRACT: Colorectal cancer (CRC) poses a significant global health challenge, with liver metastasis being a major contributor to its high mortality rate. The liver, due to its strategic anatomical location, distinctive tissue architecture, and unique metabolic properties, is the primary site for CRC to metastasize. The objective of this study was to identify hub genes involved in colorectal liver metastasis (CRLM) using a combination of bioinformatics analysis and experimental methods, and to decipher their molecular mechanisms that regulate this metastatic process. By mining data from the TCGA and GEO databases, we identified that low expression of 3-ketoacid CoA transferase 1 (OXCT1) might related to the development of CRLM. Both in vitro and in vivo experiments have indicated that

SUBMITTER: Li C 

PROVIDER: S-EPMC12765264 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature