Engineered polypeptide cascade-release platform restores macrophage plasticity for accelerated diabetic wound healing.

ABSTRACT: Persistent inflammatory episodes driven by immune cell dysregulation pose a formidable clinical challenge in diabetic wound healing. Sustained and coordinated regulation of the immune niche within diabetic wounds is critical for tissue regeneration. Here, we develop a programmed therapeutic strategy based on arginine-lysine-methionine third-generation dendrimeric polypeptides whose dopamine-coated surfaces contain ferrous ions (G3D-Pmet₂₅@PDA) to reprogram the immune niche. G3D-Pmet₂₅@PDA exhibits a core-shell structure: ferrous ions on the surface are rapidly released under near-infrared (NIR) laser irradiation, while methionine chains encapsulated within the dopamine shell undergo a reactive oxygen species (ROS) triggered hydrophilic transition that liberates argini

SUBMITTER: Xia H 

PROVIDER: S-EPMC12765269 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature