Integrative multiomics analysis reveals the ameliorative effects of Xiasangju on metabolic dysfunction-associated steatohepatitis.

ABSTRACT:

Background

Metabolic dysfunction-associated steatohepatitis (MASH) is a prevalent chronic liver disease for which safe and effective therapeutic options remain scarce. Xiasangju (XSJ), a widely consumed traditional Chinese herbal tea, exhibits diverse pharmacological activities, such as antioxidant, anti-inflammatory, and glucolipid-metabolic regulatory activities. However, its therapeutic potential for MASH has yet to be systematically explored.

Purpose

This study aims to investigate the pharmacological effects of XSJ on a MASH model induced by a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) in mice and to elucidate its potential mechanisms of action.

Methods

The chemical constituents of XSJ were identified using UPLC-Q-TOF-MS technology. Network ph

SUBMITTER: Xiang F 

PROVIDER: S-EPMC12765294 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature