Correlates of left ventricular hypertrophy in adults with coarctation of aorta and role in risk stratification.

ABSTRACT:

Background

Coarctation of aorta (COA) results in chronic left ventricular (LV) pressure overload and LV hypertrophy, which is associated with cardiovascular mortality. Therapies that decrease LV pressure overload result in regression of LV hypertrophy and improved survival. The goal of COA intervention is to relieve LV pressure overload, and the guidelines recommend the use of several COA severity indices as indications for intervention. These indices are Doppler mean gradient, systolic blood pressure (SBP), upper-to-lower-extremity SBP (ULE-SBP), aortic isthmus ratio, presence of collateral vessels, and exercise-induced hypertension (EIH). Although these indices are physiologically intuitive, it is unclear how many of these indices are required in order to recommend intervention,

SUBMITTER: Kholeif Z 

PROVIDER: S-EPMC12765328 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature