Targeting neuroinflammation and PVN^CRH neurons: dexmedetomidine liposomes for perioperative neurocognitive disorder with comorbid anxiety.

ABSTRACT: Perioperative neurocognitive disorder (PND) and anxiety are major perioperative complications that are typically managed independently, despite their frequent co-occurrence and mutual exacerbation. However, treatments for each condition have drawbacks, and no effective dual therapy exists. Here, a brain-targeted liposomal formulation (D@ACLipo) was developed for the co-delivery of the perioperative sedative dexmedetomidine (DEX) and the microglia-modulating peptide COG1410, incorporating Angiopep-2 to enhance brain penetration. In the PND mouse model, D@ACLipo pretreatment provided dual benefits, significantly alleviating surgery-induced cognitive impairment and anxiety-like behaviors with superior efficacy. As neuroinflammation is a pivotal driver of PND, mechanistic studies revealed that

SUBMITTER: Lv J 

PROVIDER: S-EPMC12765345 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature