Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma.

ABSTRACT:

Background

The relative utility of eosinophil peroxidase (EPX) and blood and sputum eosinophil counts as disease biomarkers in asthma is uncertain.

Objective

We sought to determine the utility of EPX as a biomarker of systemic and airway eosinophilic inflammation in asthma.

Methods

EPX protein was measured by immunoassay in serum and sputum in 110 healthy controls to establish a normal reference range and in repeated samples of serum and sputum collected during 3 years of observation in 480 participants in the Severe Asthma Research Program 3.

Results

Over 3 years, EPX levels in patients with asthma were higher than normal in 27% to 31% of serum samples and 36% to 53% of sputum samples. Eosinophils and EPX correlated better in blood than in sputum (r_s

SUBMITTER: Tang M 

PROVIDER: S-EPMC12765372 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature