Liver Macrophage Changes during Early Adaptation to Alcohol Exposure.

ABSTRACT: Liver macrophages consist of both Kupffer cells (KCs) and infiltrating macrophages (IMs), and both populations change during alcohol-associated liver disease. It has been suggested that KCs undergo a proinflammatory change after alcohol exposure, but the extent to which a proinflammatory shift results from IM rather than KC activation is unclear. The purpose of this study was to examine the early effects of alcohol exposure on KCs and IMs in a murine model and compare these effects with observations in human liver. Mice were fed the Lieber-Decarli ethanol diet, and total liver macrophage and KC-specific phenotypes were examined by flow cytometry, ex vivo cell culture, and KC single-cell RNA sequencing. Liver tissues from autopsy and transplant patients with different alcohol phenotypes wer

SUBMITTER: Yuquimpo K 

PROVIDER: S-EPMC12765374 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature