The relationship between cognitive screeners and everyday functioning in amyloid-positive participants from the Amsterdam Dementia Cohort.

ABSTRACT:

Introduction

We explored the relationship between cognitive screening outcomes and everyday functioning in Alzheimer's disease (AD).

Methods

A total of 1228 amyloid-positive participants were included from the Amsterdam Dementia Cohort. Multiple linear regression analyses assessed the relationship between Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and everyday functioning (Amsterdam Instrumental Activities of Daily Living Questionnaire [A-IADL-Q-30]). To link cognitive screeners to functional impairment, we described difficulties across A-IADL-Q-30 items by MMSE and MoCA quartiles.

Results

Both MMSE (B = 0.96, 95% confidence interval [CI]0.87-1.04) and MoCA (B = 0.79, 95% CI 0.68-0.89) were associated with A-IADL-Q-30. In

SUBMITTER: van der Putten-Toorenburg A 

PROVIDER: S-EPMC12765400 | biostudies-literature | 2026 Jan-Mar

REPOSITORIES: biostudies-literature