Individual and neighborhood socioeconomic inequality and the risk of dementia: A 14-year follow-up study.

ABSTRACT:

Introduction

Socioeconomic inequality is a non-negligible risk factor for dementia. However, complex associations of individual socioeconomic status (ISES) and neighborhood socioeconomic status (NSES) with dementia risk have not been determined.

Methods

In 327,641 adults aged 40-69 years from the UK Biobank, we estimated the separate, interactive, and joint associations of ISES and NSES with the risk of dementia and explored the role of inflammatory markers and metabolites.

Results

Low ISES and low NSES were associated with higher risks of all-cause dementia and its subtypes. A stronger association between ISES and dementia was observed in those with low NSES. The subpopulation with disadvantages in both ISES and NSES showed the highest risk of dementia. Inflammatory

SUBMITTER: Cao X 

PROVIDER: S-EPMC12765403 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature