Defining patient-centered amyloid PET thresholds for the onset of tauopathy in Alzheimer's disease.

ABSTRACT:

Introduction

Amyloid-induced tauopathy drives clinical decline in Alzheimer's disease (AD). Because age and sex shape tau trajectories, defining patient-centered amyloid thresholds for tauopathy onset could facilitate pre-tauopathy AD identification and aid treatment decisions and prognosis.

Methods

By including two samples (Alzheimer's Disease Neuroimaging Initiative [ADNI, n = 301]; and 18F-AV-1451-A05 [A05, n = 143]), we explored whether age and sex affect tauopathy transition and determined patient-centered amyloid positron emission tomography (PET) thresholds that mark tauopathy onset.

Results

We found a consistent amyloid PET × age interaction on global tau PET increase in men (ADNI/A05: p = 0.0078/0.018), with younger men showing faster amyloid-associated tau a

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC12765405 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature