Spatial patterns of tau accumulation across the Alzheimer's disease spectrum.

ABSTRACT:

Introduction

The spatial progression of longitudinal tau pathology has been inferred using cross-sectional data, but longitudinal voxel-wise analyses allow these patterns to be established without inference.

Methods

We pooled 1426 flortaucipir (FTP) positron emission tomography (PET) scans from 583 participants across the aging and Alzheimer's disease (AD) spectrum from four studies. Using longitudinal tau-PET slope maps, we examined tau accumulation by clinical group and its associations with participant characteristics, baseline beta-amyloid (Aβ), and tau.

Results

Tau accumulation was limited to temporoparietal cortices in unimpaired participants but widespread in patients. Baseline Aβ, entorhinal, and inferior temporal tau predicted progressively more severe tau ac

SUBMITTER: Fonseca CS 

PROVIDER: S-EPMC12765406 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature