Urinary markers in heart failure - types, timing and thresholds. European Journal of Heart Failure expert consensus document.

ABSTRACT: Several urinary markers reflect disease severity and have the potential to support the management of heart failure (HF). Collecting urine samples is easy and inexpensive, and urine sample composition can be altered not only by underlying kidney impairments (i.e. filtration barrier damage and tubular injury) but also via neurohormonal and inflammatory activation, ageing, comorbidities, other medical conditions and pharmacological interventions. For instance, urinary sodium may help to predict the response to loop diuretic therapy in acute HF, while albuminuria is used as a risk marker and therapeutic target for the progression of cardiovascular and kidney diseases in chronic HF, especially when accompanied by kidney disease. However, these markers remain underutilized in clinical practice.

SUBMITTER: Kobayashi M 

PROVIDER: S-EPMC12765416 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature