Psychological distress predicts disease activity in inflammatory bowel disease: Results from the mind-body IBD longitudinal study.

ABSTRACT:

Background & aims

Psychological distress (depression, anxiety, stress) is common in inflammatory bowel disease (IBD) and is linked to poorer outcomes, yet behavioural pathways and economic consequences remain unclear. This study tested a gut-brain-behaviour-outcome (GBBO) framework, testing: 1) reciprocal links between distress and disease activity; 2) whether health behaviours mediate distress-disease activity relationships; 3) if distress and self-reported disease activity (SRDA) predict adverse disease outcomes, controlling for inflammation and 4) whether disease activity mediates relationships between distress and adverse outcomes.

Methods

IBD patients (n = 157) reported distress, health behaviours, SRDA, healthcare use and disease-related outcomes at 3 waves at 6-month

SUBMITTER: Seaton N 

PROVIDER: S-EPMC12765445 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature