Incidence of major cardiovascular events in patients with metabolic dysfunction-associated steatotic liver disease in the general population.

ABSTRACT:

Aims

Major adverse cardiovascular events (MACE) related to cardiovascular disease are a major cause of death in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). We explored the impact of MASLD on incident MACE and overall mortality in the general population in Germany.

Methods and results

A total of 14 575 patients were included for the analysis. Elevated liver enzymes were present in 21.7% and MASLD, defined with a positive fatty liver index (FLI) in the absence of relevant alcohol use, was detected in 37% of participants. MACE were defined as a three-item composite endpoint of acute myocardial infarction (AMI), stroke and cardiovascular mortality (3-point MACE) and extended MACE (eMACE) including MACE criteria, incident atrial fibrillation an

SUBMITTER: Huber Y 

PROVIDER: S-EPMC12765464 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature