Urokinase Plasminogen Activator Receptor Attenuates Allergen-induced Eosinophil Migration and Airway Hyperresponsiveness.

ABSTRACT: Allergic asthma is a widespread disease of the airway stemming from the actions of multiple cell types, including eosinophils and epithelial cells. The urokinase plasminogen activator receptor (uPAR) is a membrane bound protein that can contribute to the activation and mobilization of leukocytes and is present at increased levels in asthmatics. However, its role in allergic asthma remains poorly understood. Here, we used multiple mouse strains and different models of allergic airway disease to study the function of uPAR in the pathogenesis of this disease. Plaur, the gene encoding uPAR, was rapidly induced following allergic sensitization through the airway, and again following subsequent allergen challenge. Plaur-deficient mice displayed both increased numbers of eosinophils

SUBMITTER: Whitehead GS 

PROVIDER: S-EPMC12765504 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature