Effect of probiotic <i>Limosilactobacillus reuteri</i> on a serum sex-hormone- and metabolic-syndrome-related health evaluation: a single-arm open-label pilot study.

ABSTRACT: The oral administration of living Limosilactobacillus reuteri (formerly Lactobacillus reuteri) ATCC PTA 6475 cells has been shown preliminarily to prevent obesity in diet-derived obese mice and to act to ameliorate the decline in serum testosterone in old male mice. Through a clinical trial comprising a single-arm open-label pilot study in which all subjects received the same intervention, the present study aimed to evaluate whether L. reuteri ATCC PTA 6475 cells can also ameliorate the decline in serum testosterone levels in senior citizens and explore how the strain changes the intestinal microbiota. The trial was conducted with 10 eligible subjects (aged 50-69) at Hiroshima University from January to April 2024. They were instructed to take two capsules that contain

SUBMITTER: Noda M 

PROVIDER: S-EPMC12765532 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature