Rapid whole-brain venous cerebral blood volume mapping using velocity-selective venous-spin-labeling with 3D GRASE.

ABSTRACT: Venous cerebral blood volume (CBV_v) is an important neurophysiological parameter and contributor to the BOLD signal mechanism. However, MRI-based, noninvasive methods for CBV_v mapping remain scarce, and existing approaches are limited by estimation errors resulting from a large-scale induced magnetic field or long scan times. To address these challenges, we have developed a rapid whole-brain 3D CBV_v mapping technique that combines velocity-selective venous-spin-labeling (VS-VSL) and a 3D gradient-and-spin-echo (GRASE) readout. In the GRASE configuration, variable refocusing flip angles were deployed for a long echo train and a short scan, with a segmented-linear center-out k-space trajectory to minimize signal modulations from alternation of gradient- and s

SUBMITTER: Heo Y 

PROVIDER: S-EPMC12765571 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature