Gastroprotective Effects of <i>Artemisia annua</i> L., on an Hydrochloric Acid/Ethanol-Induced Acute Gastritis Model via Anti-Oxidative and Anti-Inflammatory Activities.

ABSTRACT: SPB-201, a water extract of Artemisia annua L., was investigated for its gastroprotective effects against hydrochloric acid/ethanol-induced gastric mucosal injury in rats and oxidative stress-induced damage in gastric cell models, with a focus on the mechanisms underlying its antioxidant and anti-inflammatory activity. Sprague-Dawley rats pretreated with SPB-201 (50 mg/kg) showed significantly reduced gastric lesion areas, improved histological architecture, modestly decreased gastric acid secretion, and increased gastric pH compared to non-treated controls. SPB-201 significantly restored antioxidant capacity by elevating glutathione (GSH) and superoxide dismutase levels while reducing malondialdehyde levels, a marker of lipid peroxidation. SPB-201 also suppressed the mRNA and prote

SUBMITTER: Choi S 

PROVIDER: S-EPMC12765612 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature