Spinal Mincle activation as a new model of neuroinflammation-associated neuropathic pain: comparison with spinal nerve ligation.

ABSTRACT:

Background

The spinal nerve ligation (SNL) model induces neuropathic pain through peripheral nerve injury, leading to central sensitization and neuroinflammation. Recent evidence suggests that activation of Mincle (macrophage-inducible C-type lectin) in the spinal cord may also trigger pain hypersensitivity without peripheral nerve injury. This study compared the effects of SNL and spinal Mincle activation on pain behavior and neuroglial activation.

Methods

Pain hypersensitivity was evaluated following a single intrathecal (i.t.) injection of the Mincle ligand, trehalose-6,6'-dibehenate (TDB) at doses of 0.1 μg, 1 μg, or 10 μg (single injection, S-TDB). In a separate group, rats received repeated i.t. TDB injection (10 μg/day for 2 days, R-TDB) or surgery for SNL. Pain behav

SUBMITTER: Yang J 

PROVIDER: S-EPMC12765638 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature