Impact of Social Vulnerability and Allostatic Load on Postoperative Outcomes.

ABSTRACT:

Background

We sought to investigate the association between allostatic load (AL), social vulnerability, and postoperative outcomes following hepatopancreatobiliary (HPB) cancer surgery.

Methods

Individuals who underwent HPB surgery were identified using the Epic Cosmos database. AL was calculated based on 10 biomarkers across four physiological systems: cardiovascular, metabolic, renal, and immune. Multivariable regression models were used to examine the association between AL, postoperative outcomes, and failure to rescue (FTR).

Results

Among 34,253 individuals, mean patient age was 71 years (interquartile range 63-78). Approximately half of patients were male (n = 18,045, 52.7%) and had a high Charlson Comorbidity Index (CCI) score (CCI >2; n = 29,246, 85.4%). The m

SUBMITTER: Khalil M 

PROVIDER: S-EPMC12765727 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature