Pattern of Lymph Node Metastases and Recurrence in Thoracic Small Cell Esophageal Carcinoma: A Single-Institution Experience.

ABSTRACT:

Background

To study the patterns of lymph node metastases (LNMs) and associated factors, prognostic factors and failure patterns in primary thoracic small cell esophageal carcinoma (SCEC) after curative esophagectomy.

Methods

We retrospectively reviewed thoracic SCEC patients who underwent curative esophagectomy with R0 resection at Fudan University Shanghai Cancer Center. The associations between clinicopathological variables and LNM patterns were evaluated using logistic regression. The prognostic impacts on cancer-specific survival (CSS) and disease-free survival (DFS) were assessed using Cox regression models.

Results

Overall, 100/147 patients (68.0%) had LNMs (401/3560 lymph nodes, 11.3%). The frequency of LNM was 8.8% in the neck, 27.9% in the upper mediastinum

SUBMITTER: Liu D 

PROVIDER: S-EPMC12765737 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature