Prognostic Value of a Novel Staging System Integrating Lymph Node Station Number and Tumor Regression Grade for Esophageal Cancer Following Neoadjuvant Chemoradiotherapy.

ABSTRACT:

Background

The aim of this study was to evaluate the prognostic value of tumor regression grade (TRG) in patients with esophageal cancer after neoadjuvant therapy and to validate the prognostic value of a novel TRG system (nTRG) system including the number of metastatic lymph node stations (S system) in patients with esophageal cancer after neoadjuvant therapy.

Method

A total of 514 patients were enrolled in the study cohort, and survival differences between categories of the TRG or S system were tested using the Kaplan-Meier (KM) method and log-rank, with the former graded according to College of American Pathologists criteria. The nTRG system was developed by combining the two systems. We compared the discrimination, accuracy, and clinical value of the current American Joi

SUBMITTER: Liu BW 

PROVIDER: S-EPMC12765742 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature