Large Resectable Pancreatic Cancer is Associated with Futile Surgery: A Resectable But Not Curable Disease?

ABSTRACT:

Background

A subset of patients with resectable pancreatic cancer (PC) experience early recurrence after curative-intent pancreatectomy and subsequently face a poor prognosis. However, the underlying factors associated with such a futility of surgery remain unclear.

Methods

This retrospective cohort study analyzed 369 patients with resectable PC who underwent curative pancreatectomy between 2008 and 2022. Futile surgery was defined as recurrence within 8 months postoperatively. Receiver operating characteristic curve and Youden's index distribution were used to identify the optimal tumor diameter cutoff, which then was applied to survival analysis.

Results

A diameter of 3 cm corresponded to the peak of Youden's index and was adopted as the cutoff value. Patients were

SUBMITTER: Kiritani S 

PROVIDER: S-EPMC12765747 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature