Exploring the Link Between Stress-Induced Naive T-Cells and Esophageal Squamous Cell Carcinoma Risk: A Multi-Omics Investigation.

ABSTRACT:

Background

The dynamic crosstalk between immunoregulatory constituents and neoplastic evolution underscores the centrality of immune homeostasis in oncogenesis. naïve T-lymphocytes, as primary architects of adaptive immunity, are critically implicated in antitumor responses. Deciphering their mechanistic linkage to esophageal carcinogenesis is vital for elucidating immune-mediated susceptibility and malignant progression. This investigation synergizes Mendelian randomization with single-cell multi-omics to dissect this pathobiological nexus.

Methods

A bidirectional two-sample Mendelian randomization framework was deployed to infer causal associations between leukocyte subsets and esophageal squamous cell carcinoma. Genome-wide summary statistics were analyzed from 476,306 ma

SUBMITTER: Cheng J 

PROVIDER: S-EPMC12765749 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature