A low-protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy.

ABSTRACT: Despite the beneficial impact of bariatric surgery on obesity and metabolic disease, continued post-surgical obesity and weight recurrence are common, but may be impacted by diet. While guidelines recommend a post-operative high-protein diet to preserve lean mass, emerging evidence suggests that humans and mice are metabolically healthier on low-protein diets. Here, we assess the effect of varying dietary protein on post-surgical metabolism in a mouse model of sleeve gastrectomy. We find that a low-protein diet optimally drives post-surgical weight loss, boosts energy expenditure, and improves blood glucose regulation, likely, in part, due to the induction of FGF21. Through multi-omics, we identified clusters of differentially expressed genes and metabolites that correlate with these pheno

SUBMITTER: Illiano J 

PROVIDER: S-EPMC12765834 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature