Therapeutic targeting of interleukin-17C signaling in carcinogenesis of endometriosis.

ABSTRACT: Endometriosis-associated ovarian carcinoma (EAOC) predominantly arises from the malignant transformation of endometriomas, yet the mechanism is incompletely defined. Spatial transcriptomic analysis of human specimens of normal endometrium, endometriomas, and EAOC identified interleukin-17C (IL-17C) signaling activation, with higher IL-17 receptor E (IL-17RE) expression in EAOC. Additionally, the IL-17C concentration was significantly increased in the peritoneal fluid of women with ovarian cancer. Using an endometriosis mouse model overexpressing IL-17RE, IL-17C levels were elevated in the peritoneal fluid. Furthermore, IL-17C knockout reduced the peritoneal fluid IL-17C concentration and inhibited ectopic lesion growth in endometriosis mice. In addition, the role of IL-17C signaling in pro

SUBMITTER: Yao B 

PROVIDER: S-EPMC12765842 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature