HIV disrupts the lung molecular clock, leading to lung inflammation and features of emphysema.

ABSTRACT: In the aging HIV (human immunodeficiency virus)-infected population, comorbid diseases are important determinants of morbidity and mortality. People living with HIV (PLWH) demonstrate increased lung inflammation and incidence of chronic obstructive pulmonary disease (COPD), even after adjusting for smoking status. Disruption of the lung molecular clock has been implicated in the increased lung inflammation observed in COPD and smokers. We hypothesize that the expression of HIV TAT protein in the lungs of PLWHpromotes lung inflammation and features of emphysema due to dysregulation of lung circadian rhythm, determined by the lung molecular clock genes. We demonstrate that HIV TAT upregulates miR-126-3p in primary bronchial epithelial cells and suppresses Sirtuin 1 (SIRT1), resulting in down

SUBMITTER: Panda K 

PROVIDER: S-EPMC12765865 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature