Low Serum 25-Hydroxyvitamin D as a Risk Factor for Frailty in Community-Dwelling Older Men: A Korean Nationwide Study.

ABSTRACT:

Backgruound

Despite the critical role of vitamin D in various biological processes, its impact on frailty-a condition closely linked to biological age-remains inconclusive. This study aimed to explore the association between serum 25-hydroxyvitamin D (25[OH] D) levels and frailty status in older Korean adults, utilizing a comprehensive frailty index (FI) and a nationally representative dataset.

Methods

This cross-sectional study included 6,589 participants aged ≥65 years from the Korea National Health and Nutrition Examination Survey (2008-2012). Frailty was assessed using a deficit accumulation FI based on 38 physical, cognitive, psychological, and social items.

Results

After adjusting for potential confounders, frail men showed 6.8% lower serum 25(OH)D concentration

SUBMITTER: Lee J 

PROVIDER: S-EPMC12765877 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature