Linkage disequilibrium score regression identifies genetic correlations between hepatocellular carcinoma and clinically relevant traits.

ABSTRACT: Hepatocellular carcinoma (HCC) mortality is increasing globally, partly due to the growing prevalence of nonviral liver diseases. Genome-wide association studies (GWAS) have identified genetic variants associated with HCC development. Leveraging GWAS summary statistics and linkage disequilibrium score regression (LDSR), we investigated disease co-development with hepatitis C virus-negative (HCV-negative) HCC to provide unique insights into HCC etiology and prioritize relationships for further causal inquiry. We utilized the LDSR statistical framework to estimate the genetic correlation and heritability between HCV-negative HCC with 901 epidemiologic, behavioral, and clinical traits from the United Kingdom Biobank (UKBB). First, we set the threshold for observed scale heritability of each t

SUBMITTER: Han Y 

PROVIDER: S-EPMC12765977 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature